TRIB1 抗体 (AA 3-91)
Quick Overview for TRIB1 抗体 (AA 3-91) (ABIN7173357)
抗原
See all TRIB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 3-91
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Tribbles homolog 1 protein (3-91AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TRIB1 (Tribbles Homolog 1 (TRIB1))
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别名
- TRIB1
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背景
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Background: Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
Aliases: C8FW antibody, G-protein-coupled receptor-induced gene 2 protein antibody, GIG-2 antibody, GIG2 antibody, SKIP1 antibody, TRB-1 antibody, TRB1 antibody, Trib1 antibody, TRIB1_HUMAN antibody, Tribbles homolog 1 antibody
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UniProt
- Q96RU8
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途径
- Smooth Muscle Cell Migration
抗原
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