TMEM64 抗体 (AA 40-118) (Biotin)
Quick Overview for TMEM64 抗体 (AA 40-118) (Biotin) (ABIN7173258)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 40-118
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Transmembrane protein 64 protein (40-118AA)
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亚型
- IgG
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anti-Transmembrane Protein 64 (TMEM64) (AA 40-118) antibody
TMEM64 适用: 人 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TMEM64 (Transmembrane Protein 64 (TMEM64))
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别名
- TMEM64
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背景
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Background: Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.
Aliases: TMEM64 antibody, TMM64_HUMAN antibody, Transmembrane protein 64 antibody
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UniProt
- Q6YI46
抗原
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