THOC1 抗体 (AA 428-657)
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- 抗原 See all THOC1 抗体
- THOC1 (THO Complex 1 (THOC1))
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抗原表位
- AA 428-657
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This THOC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)
- 交叉反应
- 人, 小鼠
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human THO complex subunit 1 protein (428-657AA)
- 亚型
- IgG
- Top Product
- Discover our top product THOC1 Primary Antibody
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anti-THO Complex 1 (THOC1) antibody
THOC1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 1 (THOC1) (AA 428-657) antibodyTHOC1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 1 (THOC1) (C-Term) antibodyKO Validated THOC1 适用: 人 WB, IF, IP, IHC (p), ICC, ChIP 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 1 (THOC1) (C-Term) antibodyTHOC1 适用: 人, 小鼠, 大鼠, 兔, 犬, 马, 豚鼠, Cow, 斑马鱼, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 1 (THOC1) (AA 154-240) antibodyTHOC1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 1 (THOC1) (AA 511-560) antibodyTHOC1 适用: 人, 小鼠, 大鼠, 兔, 犬, 马, 豚鼠, Cow, 猴, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 1 (THOC1) (C-Term) antibodyTHOC1 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 1 (THOC1) antibodyTHOC1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-THO Complex 1 (THOC1) (AA 541-570), (C-Term) antibodyTHOC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 1 (THOC1) (AA 540-570), (C-Term) antibodyTHOC1 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- THOC1 (THO Complex 1 (THOC1))
- 别名
- THOC1 (THOC1 产品)
- 别名
- p84 antibody, MGC114861 antibody, Tho1 antibody, THOC1 antibody, Hpr1 antibody, HPR1 antibody, P84 antibody, P84N5 antibody, 3110002N20Rik antibody, AW107452 antibody, NMP-84 antibody, LRRGT00070 antibody, THO complex 1 antibody, THO complex 1 protein L homeolog antibody, THO complex subunit 1 antibody, THO complex 1 protein antibody, thoc1 antibody, thoc1.L antibody, THOC1 antibody, LOC100123388 antibody, Thoc1 antibody
- 背景
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Background: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\\\' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi\\\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.
Aliases: hTREX84 antibody, Death domain containing protein p84N5 antibody, HPR 1 antibody, HPR1 antibody, hTREX84 antibody, Nuclear matrix protein p84 antibody, P84 antibody, p84N5 antibody, Tho 1 antibody, THO complex 1 antibody, THO complex subunit 1 antibody, Tho1 antibody, THOC 1 antibody, Thoc1 antibody, THOC1_HUMAN antibody
- UniProt
- Q96FV9
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