TRF2 抗体 (AA 78-238) (Biotin)
Quick Overview for TRF2 抗体 (AA 78-238) (Biotin) (ABIN7171734)
抗原
See all TRF2 (TERF2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 78-238
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Telomeric repeat-binding factor 2 protein (78-238AA)
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亚型
- IgG
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anti-Telomeric Repeat Binding Factor 2 (TERF2) (AA 324-500) antibody
TERF2 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 3H6B4 unconjugated
anti-Telomeric Repeat Binding Factor 2 (TERF2) (AA 78-238) antibodyTERF2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2 (TERF2) antibodyTERF2 适用: 人, 小鼠, 大鼠, Deer WB, ELISA, IHC, IP, ICC, FACS, IHC (fro) 宿主: 小鼠 Monoclonal 4A794-15 unconjugated
anti-Telomeric Repeat Binding Factor 2 (TERF2) (AA 144-438) antibodyTERF2 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2 (TERF2) antibodyTERF2 适用: 人, 小鼠 WB, IHC, IP, IHC (p), ChIP 宿主: 山羊 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2 (TERF2) (AA 81-287) antibodyTERF2 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2 (TERF2) antibodyTERF2 适用: 人 WB, ELISA, IHC, IP, IF, ChIP, FACS, FM 宿主: 小鼠 Monoclonal 4A794-15 unconjugated
anti-Telomeric Repeat Binding Factor 2 (TERF2) (AA 1-251) antibodyTERF2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2 (TERF2) (C-Term) antibodyTERF2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 猴, Pig, 非洲爪蟾, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor 2 (TERF2) (C-Term) antibodyTERF2 适用: 人, 小鼠, 大鼠, 犬, Cow, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))
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别名
- TERF2
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背景
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Background: Binds the telomeric double-stranded 5\\\'-TTAGGG-3\\\' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5\\\'-TTAGGG-3\\\' repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3\\\' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
Aliases: Telomeric DNA binding protein antibody, Telomeric DNA-binding protein antibody, Telomeric repeat binding factor 2 antibody, Telomeric repeat binding protein 2 antibody, Telomeric repeat-binding factor 2 antibody, TERF 2 antibody, Terf2 antibody, TERF2_HUMAN antibody, TRBF 2 antibody, TRBF2 antibody, TRF 2 antibody, TRF2 antibody, TTAGGG repeat binding factor 2 antibody, TTAGGG repeat-binding factor 2 antibody
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UniProt
- Q15554
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途径
- Cell Division Cycle, Telomere Maintenance
抗原
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