MAPKAP1 抗体 (AA 1-290)
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北京 101111
Quick Overview for MAPKAP1 抗体 (AA 1-290) (ABIN7171521)
抗原
See all MAPKAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-290
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原理
- MAPKAP1 Antibody
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Target of rapamycin complex 2 subunit MAPKAP1 protein (1-290AA)
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) (AA 8-236) antibody
MAPKAP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) (AA 370-486) antibodyMAPKAP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) (AA 100-150) antibodyMAPKAP1 适用: 人, 小鼠, 大鼠, 犬, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) (AA 85-102) antibodyMAPKAP1 适用: 人, 小鼠, 大鼠, 犬, Cow, 小鸡, 马, 绵羊, Bat, 猴, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))
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别名
- MAPKAP1
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背景
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Background: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 \\\'Ser-473\\\' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on \\\'Thr-308\\\' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at \\\'Ser-422\\\'. mTORC2 also modulates the phosphorylation of PRKCA on \\\'Ser-657\\\'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.
Aliases: MAPKAP 1 antibody, MAPKAP1 antibody, MEKK2 interacting protein 1 antibody, MGC2745 antibody, MIP 1 antibody, MIP1 antibody, Mitogen activated protein kinase associated protein 1 antibody, Mitogen-activated protein kinase 2-associated protein 1 antibody, mSIN1 antibody, OTTHUMP00000064207 antibody, Ras inhibitor MGC2745 antibody, SAPK interacting protein 1 antibody, SAPK-interacting protein 1 antibody, SIN 1 antibody, SIN1_HUMAN antibody, SIN1b antibody, SIN1g antibody, Stress activated map kinase interacting protein 1 antibody, Stress activated protein kinase interacting 1 antibody, Stress-activated map kinase-interacting protein 1 antibody, Target of rapamycin complex 2 subunit MAPKAP1 antibody, TORC2 subunit MAPKAP1 antibody
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UniProt
- Q9BPZ7
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途径
- PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events
抗原
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