TNKS2 抗体 (AA 1-246) (Biotin)
Quick Overview for TNKS2 抗体 (AA 1-246) (Biotin) (ABIN7171501)
抗原
See all TNKS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-246
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Tankyrase-2 protein (1-246AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))
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别名
- TNKS2
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背景
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Background: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.
Aliases: ADP-ribosyltransferase diphtheria toxin-like 6 antibody, ARTD6 antibody, PARP 5b antibody, PARP 5c antibody, PARP-5b antibody, PARP-5c antibody, PARP5B antibody, PARP5C antibody, pART6 antibody, Poly [ADP ribose] polymerase 5B antibody, Poly [ADP-ribose] polymerase 5B antibody, TANK2 antibody, Tankyrase 2 antibody, Tankyrase II antibody, Tankyrase like protein antibody, Tankyrase related protein antibody, Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2 antibody, Tankyrase-2 antibody, Tankyrase-like protein antibody, Tankyrase-related protein antibody, TNKL antibody, TNKS 2 antibody, TNKS-2 antibody, TNKS2 antibody, TNKS2_HUMAN antibody, TRF1 Interacting Ankyrin Related ADP ribose polymerase 2 antibody, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antibody
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UniProt
- Q9H2K2
抗原
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