SMC5 抗体 (AA 296-403) (Biotin)
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Quick Overview for SMC5 抗体 (AA 296-403) (Biotin) (ABIN7170871)
抗原
See all SMC5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 296-403
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原理
- SMC5 Antibody, Biotin conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA)
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亚型
- IgG
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anti-Structural Maintenance of Chromosomes 5 (SMC5) (AA 872-1101) antibody
SMC5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 5 (SMC5) (Internal Region) antibodyVerified SMC5 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 5 (SMC5) (AA 296-403) antibodySMC5 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 5 (SMC5) (AA 992-1101) antibodySMC5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))
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别名
- SMC5
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背景
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Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).
Aliases: SMC5 antibody, KIAA0594 antibody, SMC5L1 antibody, Structural maintenance of chromosomes protein 5 antibody, SMC protein 5 antibody, SMC-5 antibody, hSMC5 antibody
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UniProt
- Q8IY18
抗原
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