ESRRB 抗体 (AA 432-502)
Quick Overview for ESRRB 抗体 (AA 432-502) (ABIN7170762)
抗原
See all ESRRB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 432-502
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Steroid hormone receptor ERR2 protein (432-502AA)
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亚型
- IgG
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anti-Estrogen-Related Receptor beta (ESRRB) (AA 275-305) antibody
ESRRB 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB17738 unconjugated
anti-Estrogen-Related Receptor beta (ESRRB) (AA 166-438) antibodyESRRB 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Estrogen-Related Receptor beta (ESRRB) (Ligand Binding Domain) antibodyESRRB 适用: 人, 马, 犬, Cow, 兔, 猴, Pig, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Estrogen-Related Receptor beta (ESRRB) (N-Term) antibodyESRRB 适用: 人, 马, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Estrogen-Related Receptor beta (ESRRB) (Internal Region) antibodyESRRB 适用: 人, 马, 猴, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Estrogen-Related Receptor beta (ESRRB) (AA 283-312), (Middle Region) antibodyESRRB 适用: 人 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Estrogen-Related Receptor beta (ESRRB) (AA 1-100) antibodyESRRB 适用: 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Estrogen-Related Receptor beta (ESRRB) (AA 38-87) antibodyESRRB 适用: 人, 马, 犬, Cow, 豚鼠, 猴, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Estrogen-Related Receptor beta (ESRRB) (N-Term) antibodyESRRB 适用: 人, 小鼠, 大鼠, 马, 犬, Cow, 豚鼠, 猴, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Estrogen-Related Receptor beta (ESRRB) (N-Term) antibodyESRRB 适用: 人, 小鼠, 大鼠, 马, 犬, Cow, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- ESRRB (Estrogen-Related Receptor beta (ESRRB))
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别名
- ESRRB
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背景
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Background: Isoform 3: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5\\\'TCAAGGTCA-3\\\' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity).
Aliases: Err 2 antibody, ERR b antibody, ERR B2 antibody, ERR beta 2 antibody, ERR beta antibody, ERR beta-2 antibody, ERR-beta antibody, Err2 antibody, ERR2_HUMAN antibody, ERRB 2 antibody, ERRb antibody, ERRB2 antibody, ERRbeta 2 antibody, ERRbeta antibody, ESR L2 antibody, ESRL 2 antibody, ESRL2 antibody, Esrrb antibody, Estrogen receptor like 2 antibody, Estrogen receptor related 2 antibody, Estrogen receptor-like 2 antibody, Estrogen-related receptor beta antibody, Estrrb antibody, Nr3b2 antibody, Nuclear receptor ERRB2 antibody, Nuclear receptor subfamily 3 group B member 2 antibody, Orphan nuclear receptor antibody, Steroid hormone receptor ERR 2 antibody, Steroid hormone receptor ERR2 antibody
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UniProt
- O95718
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途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance
抗原
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