Spartan 抗体 (AA 1-239)
Quick Overview for Spartan 抗体 (AA 1-239) (ABIN7170650)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-239
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human SprT-like domain-containing protein Spartan protein (1-239AA)
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亚型
- IgG
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anti-Chromosome 1 Open Reading Frame 124 (C1orf124) antibody
C1orf124 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 124 (C1orf124) (AA 1-489) antibodyC1orf124 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 124 (C1orf124) (AA 186-235) antibodyC1orf124 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 124 (C1orf124) (AA 1-240) antibodyC1orf124 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))
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别名
- SPRTN
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背景
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Background: Regulator of UV-induced DNA damage response: acts as a \'reader\' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.
Aliases: SPRTN antibody, C1orf124 antibody, DVC1 antibody, UNQ1880/PRO4323 antibody, SprT-like domain-containing protein Spartan antibody, DNA damage protein targeting VCP antibody, DVC1 antibody, Protein with SprT-like domain at the N terminus antibody, Spartan antibody
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UniProt
- Q9H040
抗原
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