SNX6 抗体 (AA 1-290)
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北京 101111
Quick Overview for SNX6 抗体 (AA 1-290) (ABIN7170402)
抗原
See all SNX6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-290
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原理
- SNX6 Antibody
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human Sorting nexin-6 protein (1-290AA)
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亚型
- IgG
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anti-Sorting Nexin 6 (SNX6) antibody
SNX6 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 6 (SNX6) (AA 1-290) antibodySNX6 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 3B11 unconjugated
anti-Sorting Nexin 6 (SNX6) (AA 211-310) antibodySNX6 适用: 小鼠, 大鼠 ELISA, WB, ICC, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 6 (SNX6) (AA 208-257) antibodySNX6 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SNX6 (Sorting Nexin 6 (SNX6))
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别名
- SNX6
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背景
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Background: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation, inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).
Aliases: SNX6 antibody, Sorting nexin-6 antibody, TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6 antibody, N-terminally processed] antibody
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UniProt
- Q9UNH7
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途径
- EGFR Signaling Pathway
抗原
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