SPPL3 抗体 (AA 213-263)
Quick Overview for SPPL3 抗体 (AA 213-263) (ABIN7169631)
抗原
See all SPPL3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 213-263
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA)
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亚型
- IgG
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anti-Signal Peptide Peptidase 3 (SPPL3) (AA 215-264) antibody
SPPL3 适用: 人, 小鸡, Cow, 豚鼠, 马, 猴, 小鼠, Pig, 兔, 大鼠, 非洲爪蟾, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:200-1:2000, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SPPL3 (Signal Peptide Peptidase 3 (SPPL3))
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别名
- SPPL3
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背景
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Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).
Aliases: SPPL3 antibody, IMP2 antibody, PSL4 antibody, Signal peptide peptidase-like 3 antibody, SPP-like 3 antibody, EC 3.4.23.- antibody, Intramembrane protease 2 antibody, IMP-2 antibody, Presenilin homologous protein 1 antibody, PSH1 antibody, Presenilin-like protein 4 antibody
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UniProt
- Q8TCT6
抗原
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