SH2D1B 抗体 (AA 1-77) (Biotin)
Quick Overview for SH2D1B 抗体 (AA 1-77) (Biotin) (ABIN7169454)
抗原
See all SH2D1B 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-77
-
交叉反应
- 人
-
纯化方法
- >95%, Protein G purified
-
免疫原
- Recombinant Human SH2 domain-containing protein 1B protein (1-77AA)
-
亚型
- IgG
-
-
anti-SH2 Domain Containing 1B (SH2D1B) (AA 1-77) antibody
SH2D1B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1B (SH2D1B) (AA 1-132) antibodySH2D1B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1B (SH2D1B) (AA 54-132) antibodySH2D1B 适用: 人 ELISA, IP 宿主: 小鼠 Monoclonal 2B4 unconjugated
anti-SH2 Domain Containing 1B (SH2D1B) (AA 1-132) antibodySH2D1B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- SH2D1B (SH2 Domain Containing 1B (SH2D1B))
-
别名
- SH2D1B
-
背景
-
Background: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation, downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine procuction dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).
Aliases: SH2D1B antibody, EAT2 antibody, SH2 domain-containing protein 1B antibody, EWS/FLI1-activated transcript 2 antibody, EAT-2 antibody
-
UniProt
- O14796
-
途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
-
