SESN1 抗体 (AA 224-337) (Biotin)
Quick Overview for SESN1 抗体 (AA 224-337) (Biotin) (ABIN7169406)
抗原
See all SESN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 224-337
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Sestrin-1 protein (224-337AA)
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亚型
- IgG
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anti-Sestrin 1 (SESN1) (AA 1-551) antibody
SESN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) antibodySESN1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 224-337) antibodySESN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 271-370) antibodySESN1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 1-551) antibodySESN1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 312-341), (C-Term) antibodySESN1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB18601 unconjugated
anti-Sestrin 1 (SESN1) (AA 45-492) antibodySESN1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 375-424) antibodySESN1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (C-Term) antibodySESN1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 1 (SESN1) (AA 14-43), (N-Term) antibodySESN1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB18600 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SESN1 (Sestrin 1 (SESN1))
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别名
- SESN1
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背景
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Background: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity).
Aliases: 1110002G11Rik antibody, AU044290 antibody, MGC118148 antibody, MGC138241 antibody, MGC142129 antibody, OTTMUSP00000022799 antibody, p53 activated gene 26 antibody, p53 regulated PA26 nuclear protein antibody, p53 regulated protein PA26 antibody, p53-regulated protein PA26 antibody, PA26 antibody, RP11-787I22.1 antibody, sesn1 antibody, SESN1_HUMAN antibody, SEST1 antibody, sestrin 1 antibody, Sestrin-1 antibody
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UniProt
- Q9Y6P5
抗原
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