WNK3 抗体 (AA 1018-1181)
Quick Overview for WNK3 抗体 (AA 1018-1181) (ABIN7169230)
抗原
See all WNK3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1018-1181
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Serine/threonine-protein kinase WNK3 protein (1018-1181AA)
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亚型
- IgG
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应用备注
- Recommended dilution: IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- WNK3 (WNK Lysine Deficient Protein Kinase 3 (WNK3))
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别名
- WNK3
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背景
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Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.
Aliases: KIAA1566 antibody, PRKWNK 3 antibody, PRKWNK3 antibody, Protein kinase lysine deficient 3 antibody, Protein kinase lysine-deficient 3 antibody, Protein kinase with no lysine 3 antibody, Serine/threonine protein kinase WNK3 antibody, Serine/threonine-protein kinase WNK3 antibody, WNK 3 antibody, WNK lysine deficient protein kinase 3 antibody, Wnk3 antibody, WNK3_HUMAN antibody
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UniProt
- Q9BYP7
抗原
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