WNK2 抗体 (AA 1177-1464) (Biotin)
Quick Overview for WNK2 抗体 (AA 1177-1464) (Biotin) (ABIN7169227)
抗原
See all WNK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1177-1464
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Serine/threonine-protein kinase WNK2 protein (1177-1464AA)
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亚型
- IgG
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anti-WNK Lysine Deficient Protein Kinase 2 (WNK2) (AA 1177-1464) antibody
WNK2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 2 (WNK2) (AA 2118-2217) antibodyWNK2 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 2E10 unconjugated
anti-WNK Lysine Deficient Protein Kinase 2 (WNK2) antibodyWNK2 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 2 (WNK2) (AA 2118-2217) antibodyWNK2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2A2 unconjugated
anti-WNK Lysine Deficient Protein Kinase 2 (WNK2) (Internal Region) antibodyWNK2 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- WNK2 (WNK Lysine Deficient Protein Kinase 2 (WNK2))
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别名
- WNK2
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背景
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Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
Aliases: WNK2 antibody, KIAA1760 antibody, PRKWNK2 antibody, SDCCAG43 antibody, P/OKcl.13 antibody, Serine/threonine-protein kinase WNK2 antibody, EC 2.7.11.1 antibody, Antigen NY-CO-43 antibody, Protein kinase lysine-deficient 2 antibody, Protein kinase with no lysine 2 antibody, Serologically defined colon cancer antigen 43 antibody
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UniProt
- Q9Y3S1
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途径
- Photoperiodism
抗原
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