PIM2 抗体 (AA 1-210)
Quick Overview for PIM2 抗体 (AA 1-210) (ABIN7169145)
抗原
See all PIM2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-210
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Serine/threonine-protein kinase pim-2 protein (1-210AA)
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亚型
- IgG
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anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) antibody
PIM2 适用: 人 WB, IHC, IP, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 9A5 unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (AA 277-308), (C-Term) antibodyPIM2 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal RB01288 unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (Center) antibodyPIM2 适用: 人, 小鼠 WB, IP, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (AA 23-36) antibodyVerified PIM2 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (C-Term) antibodyVerified PIM2 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (AA 1-311) antibodyPIM2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (N-Term) antibodyPIM2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) antibodyPIM2 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) antibodyPIM2 适用: 人 WB, IHC, IP, IF, FACS 宿主: 小鼠 Monoclonal 8H10 unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) antibodyPIM2 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))
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别名
- PIM2
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背景
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Background: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade, this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Aliases: OTTHUMP00000025825 antibody, Pim 2 oncogene antibody, Pim 2h antibody, Pim-2h antibody, PIM2 antibody, PIM2 Oncogene antibody, PIM2_HUMAN antibody, Pim2h antibody, Proto Oncogene PIM2 antibody, Proto-oncogene Pim-2 (serine threonine kinase) antibody, Serine/threonine kinase PIM2 antibody, Serine/threonine-protein kinase Pim-2 antibody
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UniProt
- Q9P1W9
抗原
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