SRSF1 抗体 (AA 1-248)
Quick Overview for SRSF1 抗体 (AA 1-248) (ABIN7168966)
抗原
See all SRSF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-248
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Serine/arginine-rich splicing factor 1 protein (1-248AA)
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亚型
- IgG
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应用备注
- Recommended dilution: IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))
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别名
- SRSF1
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背景
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Background: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5\\\'- and 3\\\'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5\\\'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5\\\'-RGAAGAAC-3\\\' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5\\\'-CGAGGCG-3\\\' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.
Aliases: Alternative splicing factor 1 antibody, Alternative-splicing factor 1 antibody, arginine/serine-rich 1 antibody, ASF 1 antibody, ASF antibody, ASF-1 antibody, ASF1 antibody, FLJ53078 antibody, MGC5228 antibody, P33 subunit antibody, Pre mRNA splicing factor SF2 P33 subunit antibody, pre-mRNA-splicing factor SF2 antibody, Serine/arginine-rich splicing factor 1 antibody, SF2 antibody, SF2P33 antibody, SFRS1 antibody, Splicing factor 2 alternate splicing factor antibody, Splicing factor 2 antibody, Splicing factor antibody, Splicing factor arginine/serine rich 1 antibody, SR Splicing factor 1 antibody, SRp30a antibody, srsf1 antibody, SRSF1_HUMAN antibody
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UniProt
- Q07955
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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