Selenoprotein N 抗体 (AA 135-219)
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北京 101111
Quick Overview for Selenoprotein N 抗体 (AA 135-219) (ABIN7168771)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 135-219
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原理
- SELENON Antibody
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交叉反应
- 大鼠
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human Selenoprotein N protein (135-219AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Selenoprotein N (SELENON)
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别名
- SELENON
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背景
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Background: Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863).
Aliases: CFTD antibody, MDRS1 antibody, RSMD1 antibody, RSS antibody, Selenoprotein N antibody, Selenoprotein N, 1 antibody, SelN antibody, SELN_HUMAN antibody, sepn1 antibody
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UniProt
- Q9NZV5
抗原
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