RC3H2 抗体 (AA 251-506) (FITC)
Quick Overview for RC3H2 抗体 (AA 251-506) (FITC) (ABIN7168434)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 251-506
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Roquin-2 protein (251-506AA)
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亚型
- IgG
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anti-Membrane Associated DNA Binding Protein (RC3H2) (Middle Region) antibody
RC3H2 适用: 人, Cow, 犬, 豚鼠, 马, 小鼠, 兔, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Membrane Associated DNA Binding Protein (RC3H2) (AA 748-847) antibodyRC3H2 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Membrane Associated DNA Binding Protein (RC3H2) (AA 395-444) antibodyRC3H2 适用: 人, Cow, 犬, 豚鼠, 马, 小鼠, 兔, 大鼠, Bat, 小鸡, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Membrane Associated DNA Binding Protein (RC3H2) (Middle Region) antibodyRC3H2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- RC3H2 (Membrane Associated DNA Binding Protein (RC3H2))
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别名
- RC3H2
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背景
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Background: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3\'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation. May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (PubMed:24448648).
Aliases: 2900024N03Rik antibody, 9430019J22Rik antibody, D930043C02Rik antibody, FLJ20301 antibody, FLJ20713 antibody, Membrane associated DNA binding protein antibody, Membrane associated nucleic acid binding protein antibody, Membrane-associated nucleic acid-binding protein antibody, MGC52176 antibody, MNAB antibody, OTTHUMP00000022076 antibody, OTTHUMP00000022077 antibody, OTTMUSP00000013545 antibody, OTTMUSP00000013546 antibody, Rc3h2 antibody, RC3H2_HUMAN antibody, Ring finger and CCCH type domains 2 antibody, RING finger and CCCH type zinc finger domain containing protein 2 antibody, Ring finger and CCCH-type zinc finger domain-containing protein 2 antibody, ring finger and CCCH-type zinc finger domains 2 antibody, RING finger protein 164 antibody, RNF164 antibody, roquin-2 antibody, RP23-321B3.1 antibody
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UniProt
- Q9HBD1
抗原
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