TARBP2 抗体 (AA 1-366)
Quick Overview for TARBP2 抗体 (AA 1-366) (ABIN7168268)
抗原
See all TARBP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-366
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human RISC-loading complex subunit TARBP2 protein (1-366AA)
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亚型
- IgG
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应用备注
- Recommended dilution: IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))
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别名
- TARBP2
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背景
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Background: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.
Aliases: LOQS antibody, Prbp antibody, RISC loading complex subunit TARBP2 antibody, RISC-loading complex subunit tarbp2 antibody, TAR (HIV 1) RNA binding protein 2 antibody, TAR (HIV) RNA binding protein 2 antibody, TAR (HIV) RNA-binding protein TRBP1 antibody, TAR RNA Binding Protein 2 antibody, TAR RNA-binding protein 2 antibody, tarbp2 antibody, TARBP2 RISC loading complex RNA binding subunit antibody, Trans-activation-responsive RNA-binding protein antibody, TRBP antibody, TRBP1 antibody, TRBP2 antibody, TRBP2_HUMAN antibody
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UniProt
- Q15633
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途径
- Regulatory RNA Pathways, Ribonucleoprotein Complex Subunit Organization
抗原
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