Chemerin 抗体 (AA 21-157)
Quick Overview for Chemerin 抗体 (AA 21-157) (ABIN7167807)
抗原
See all Chemerin (RARRES2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-157
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Retinoic acid receptor responder protein 2 protein (21-157AA)
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亚型
- IgG
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anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 17-163) antibody
RARRES2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 81-163) antibodyRARRES2 适用: 人, 大鼠, 小鼠, 兔 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 1-35) antibodyRARRES2 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB56708 unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 17-163) antibodyRARRES2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E3 unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 1-163) antibodyRARRES2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 89-133) antibodyRARRES2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB56709 unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 1-163) antibodyRARRES2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 33-158) antibodyRARRES2 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))
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别名
- RARRES2
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背景
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Background: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.
Aliases: HP10433 antibody, RAR responsive protein TIG2 antibody, RAR-responsive protein TIG2 antibody, RARR2_HUMAN antibody, RARRES2 antibody, Retinoic acid receptor responder (tazarotene induced) 2 antibody, Retinoic acid receptor responder 2 antibody, Retinoic acid receptor responder protein 2 antibody, Tazarotene induced gene 2 protein antibody, Tazarotene-induced gene 2 protein antibody, TIG2 antibody
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UniProt
- Q99969
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途径
- Brown Fat Cell Differentiation
抗原
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