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Chemerin 抗体 (AA 21-157)

This anti-Chemerin antibody is a 兔 多克隆 antibody detecting Chemerin in ELISA, IHC 和 IF. Suitable for 人.
产品编号 ABIN7167807
发货至: 中国

Quick Overview for Chemerin 抗体 (AA 21-157) (ABIN7167807)

抗原

See all Chemerin (RARRES2) 抗体
Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))

适用

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宿主

  • 47
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克隆类型

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多克隆

标记

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This Chemerin antibody is un-conjugated

应用范围

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ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
  • 抗原表位

    • 15
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    AA 21-157

    交叉反应

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human Retinoic acid receptor responder protein 2 protein (21-157AA)

    亚型

    IgG
  • 应用备注

    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))

    别名

    RARRES2

    背景

    Background: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.

    Aliases: HP10433 antibody, RAR responsive protein TIG2 antibody, RAR-responsive protein TIG2 antibody, RARR2_HUMAN antibody, RARRES2 antibody, Retinoic acid receptor responder (tazarotene induced) 2 antibody, Retinoic acid receptor responder 2 antibody, Retinoic acid receptor responder protein 2 antibody, Tazarotene induced gene 2 protein antibody, Tazarotene-induced gene 2 protein antibody, TIG2 antibody

    UniProt

    Q99969

    途径

    Brown Fat Cell Differentiation
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