RGMA 抗体 (AA 153-408)
Quick Overview for RGMA 抗体 (AA 153-408) (ABIN7167709)
抗原
See all RGMA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 153-408
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交叉反应
- 人, 小鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Repulsive guidance molecule A protein (153-408AA)
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亚型
- IgG
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anti-RGM Domain Family, Member A (RGMA) (AA 326-423) antibody
RGMA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6D7 unconjugated
anti-RGM Domain Family, Member A (RGMA) antibodyRGMA 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- RGMA (RGM Domain Family, Member A (RGMA))
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别名
- RGMA
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背景
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Background: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Aliases: Repulsive guidance molecule A antibody, RGM antibody, RGM domain family member A antibody, RGMA antibody, RGMA_HUMAN antibody
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UniProt
- Q96B86
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途径
- Tube Formation
抗原
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