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REST 抗体 (AA 250-350)

This 兔 多克隆 antibody specifically detects REST in ELISA 和 IF. It exhibits reactivity toward 人.
产品编号 ABIN7167425
发货至: 中国
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Quick Overview for REST 抗体 (AA 250-350) (ABIN7167425)

抗原

See all REST 抗体
REST (RE1-Silencing Transcription Factor (REST))

适用

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宿主

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克隆类型

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多克隆

标记

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This REST antibody is un-conjugated

应用范围

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ELISA, Immunofluorescence (IF)
  • 抗原表位

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    AA 250-350

    原理

    REST Antibody

    纯化方法

    Protein G purified

    纯度

    >95 %

    免疫原

    Recombinant Human RE1-silencing transcription factor protein (250-350AA)

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    REST (RE1-Silencing Transcription Factor (REST))

    别名

    REST

    背景

    Background: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

    Aliases: Neural Restrictive Silencer Factor antibody, Neural-restrictive silencer factor antibody, Neuron Restrictive Silencer Factor antibody, NRSF antibody, RE1 silencing transcription factor antibody, RE1-silencing transcription factor antibody, Repressor binding to the X2 box antibody, rest antibody, REST protein antibody, REST_HUMAN antibody, X2 box repressor antibody, XBR antibody

    UniProt

    Q13127

    途径

    Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity
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