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RAB7A 抗体 (AA 110-177) (HRP)

This anti-RAB7A antibody (ABIN7167380) is a Rabbit Polyclonal antibody detecting RAB7A in ELISA. Suitable for Human.
产品编号 ABIN7167380
发货至: 中国

Quick Overview for RAB7A 抗体 (AA 110-177) (HRP) (ABIN7167380)

抗原

See all RAB7A 抗体
RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

适用

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宿主

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克隆类型

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多克隆

标记

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This RAB7A antibody is conjugated to HRP

应用范围

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ELISA
  • 抗原表位

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    AA 110-177

    交叉反应

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human Ras-related protein Rab-7a protein (110-177AA)

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

    别名

    RAB7A

    背景

    Background: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

    Aliases: CMT2B antibody, PRO2706 antibody, PSN antibody, RAB7, member RAS oncogene family antibody, RAB7A antibody, RAB7A, member RAS oncogene family antibody, RAB7A_HUMAN antibody, Ras associated protein RAB7 antibody, Ras related protein Rab7 antibody, Ras related protein Rab7a antibody, Ras-related protein Rab-7a antibody

    UniProt

    P51149

    途径

    EGFR Signaling Pathway, Maintenance of Protein Location, SARS-CoV-2 Protein Interactome
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