RASGRP1 抗体 (AA 594-716)
Quick Overview for RASGRP1 抗体 (AA 594-716) (ABIN7167163)
抗原
See all RASGRP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 594-716
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human RAS guanyl-releasing protein 1 protein (594-716AA)
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亚型
- IgG
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anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (AA 598-797) antibody
RASGRP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (AA 495-521) antibodyRASGRP1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21940 unconjugated
anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (AA 617-666) antibodyRASGRP1 适用: 人, 豚鼠, 小鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))
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别名
- RASGRP1
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背景
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Background: Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).
Aliases: RASGRP1 antibody, RASGRPRAS guanyl-releasing protein 1 antibody, Calcium and DAG-regulated guanine nucleotide exchange factor II antibody, CalDAG-GEFII antibody, Ras guanyl-releasing protein antibody
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UniProt
- O95267
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
抗原
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