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RASSF1 抗体 (AA 23-145)

This 兔 多克隆 antibody specifically detects RASSF1 in ELISA 和 IHC. It exhibits reactivity toward 人.
产品编号 ABIN7167122
发货至: 中国
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Quick Overview for RASSF1 抗体 (AA 23-145) (ABIN7167122)

抗原

See all RASSF1 抗体
RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

适用

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宿主

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克隆类型

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多克隆

标记

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This RASSF1 antibody is un-conjugated

应用范围

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ELISA, Immunohistochemistry (IHC)
  • 抗原表位

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    AA 23-145

    原理

    RASSF1 Antibody

    纯化方法

    Protein G purified

    纯度

    >95 %

    免疫原

    Recombinant Human Ras association domain-containing protein 1 protein (23-145AA)

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

    别名

    RASSF1

    背景

    Background: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

    Aliases: 123F2 antibody, Cardiac specific ras association domain family 1 protein antibody, cardiac-specific ras association domain family 1 protein, 123F2 antibody, NORE2A antibody, OTTHUMP00000195503 antibody, OTTHUMP00000195504 antibody, OTTHUMP00000195505 antibody, OTTHUMP00000195507 antibody, Pancreas specific ras association domain family 1 protein antibody, Ras association (RalGDS/AF 6) domain family member 1 antibody, Ras association domain-containing protein 1 antibody, RASF1_HUMAN antibody, Rassf1 antibody, RASSF1A antibody, RDA32 antibody, REH3P21 antibody, Tumor suppressor protein RDA32 antibody, WUGSC:H_LUCA12.5 antibody

    UniProt

    Q9NS23
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