RAPGEF2 抗体 (AA 1393-1498)
Quick Overview for RAPGEF2 抗体 (AA 1393-1498) (ABIN7167104)
抗原
See all RAPGEF2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1393-1498
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Rap guanine nucleotide exchange factor 2 protein (1393-1498AA)
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亚型
- IgG
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anti-Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2) (AA 1398-1487) antibody
RAPGEF2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E8 unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2) (C-Term) antibodyRAPGEF2 适用: 人, 小鼠, 犬, 马, 兔, 大鼠, Cow, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2) (AA 1464-1498), (C-Term) antibodyRAPGEF2 适用: 人 WB 宿主: 兔 Polyclonal RB52925 unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2) (AA 1398-1487) antibodyRAPGEF2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2) (Middle Region) antibodyRAPGEF2 适用: 人, 小鼠, 犬, 马, 兔, 大鼠, Cow, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))
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别名
- RAPGEF2
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背景
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Background: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.
Aliases: CNrasGEF antibody, Cyclic nucleotide ras GEF antibody, KIAA0313 antibody, Neural RAP guanine nucleotide exchange protein antibody, nRap GEP antibody, NRAPGEP antibody, PDZ domain containing guanine nucleotide exchange factor 1 antibody, PDZ domain-containing guanine nucleotide exchange factor 1 antibody, PDZ GEF1 antibody, PDZ-GEF1 antibody, PDZGEF1 antibody, RA GEF antibody, RA-GEF-1 antibody, Rap guanine nucleotide exchange factor 2 antibody, Rapgef2 antibody, Ras/Rap1-associating GEF-1 antibody, RPGF2_HUMAN antibody
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UniProt
- Q9Y4G8
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途径
- Neurotrophin Signaling Pathway
抗原
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