MEFV 抗体 (AA 268-374)
Quick Overview for MEFV 抗体 (AA 268-374) (ABIN7166884)
抗原
See all MEFV 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 268-374
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Pyrin protein (268-374AA)
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亚型
- IgG
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anti-Mediterranean Fever (MEFV) (AA 1-110) antibody
MEFV 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2C1 unconjugated
anti-Mediterranean Fever (MEFV) (AA 1-110) antibodyMEFV 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Mediterranean Fever (MEFV) (Internal Region) antibodyVerified MEFV 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Mediterranean Fever (MEFV) (N-Term) antibodyMEFV 适用: 人, 小鼠, 犬, Cow, 豚鼠, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Mediterranean Fever (MEFV) (AA 418-445) antibodyMEFV 适用: 人 WB 宿主: 兔 Polyclonal RB41739 unconjugated
anti-Mediterranean Fever (MEFV) (N-Term) antibodyMEFV 适用: 人, 马, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:200-1:500,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- MEFV (Mediterranean Fever (MEFV))
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别名
- MEFV
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背景
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Background: Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production (PubMed:16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923).
Aliases: FMF antibody, Marenostrin antibody, Mediterranean fever antibody, Mediterranean fever protein antibody, MEF antibody, Mefv antibody, MEFV_HUMAN antibody, Pyrin antibody, TRIM20 antibody
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UniProt
- O15553
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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