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CRBN 抗体 (AA 1-280)

This anti-CRBN antibody is a 兔 多克隆 antibody detecting CRBN in WB, IHC 和 ELISA. Suitable for 人.
产品编号 ABIN7165198
发货至: 中国

Quick Overview for CRBN 抗体 (AA 1-280) (ABIN7165198)

抗原

See all CRBN 抗体
CRBN (Cereblon (CRBN))

适用

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宿主

  • 32
  • 3

克隆类型

  • 34
  • 1
多克隆

标记

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This CRBN antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • Key Features

    • Rabbit anti-CRBN Antibody reliably detects CRBN in human species.
    • Polyclonal, unconjugated antibody for ELISA, WB, IHC.
    • Highly specific CRBN detection. See validation images.

    抗原表位

    • 15
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-280

    交叉反应

    人, 小鼠

    纯化方法

    Antigen Affinity Purified

    免疫原

    Recombinant Human Protein cereblon protein (1-280AA)

    亚型

    IgG
  • 应用备注

    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    CRBN (Cereblon (CRBN))

    别名

    CRBN

    背景

    Background: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.

    Aliases: 2610203G15Rik antibody, 2900045O07Rik antibody, AF229032 antibody, AW108261 antibody, Cereblon antibody, Crbn antibody, CRBN_HUMAN antibody, DKFZp781K0715 antibody, MGC27358 antibody, MRT2A antibody, OTTHUMP00000209555 antibody, piL antibody, Protein cereblon antibody, Protein x 0001 antibody

    UniProt

    Q96SW2
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