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POT1 抗体 (AA 250-432) (Biotin)

POT1 适用: 人 ELISA 宿主: 兔 Polyclonal Biotin
产品编号 ABIN7164999
发货至: 中国
  • 抗原 See all POT1 抗体
    POT1 (Protection of Telomeres 1 (POT1))
    抗原表位
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 250-432
    适用
    • 24
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 23
    • 1
    克隆类型
    • 23
    • 1
    多克隆
    标记
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This POT1 antibody is conjugated to Biotin
    应用范围
    • 14
    • 8
    • 2
    • 2
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Protection of telomeres protein 1 protein (250-432AA)
    亚型
    IgG
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    POT1 (Protection of Telomeres 1 (POT1))
    别名
    POT1 (POT1 产品)
    别名
    HPOT1 antibody, POT1 antibody, DKFZp469P1825 antibody, pot1 antibody, 1500031H18Rik antibody, AI851169 antibody, Pot1 antibody, Pot1a antibody, protection of telomeres 1 antibody, protection of telomeres 1 L homeolog antibody, protection of telomeres 1A antibody, POT1 antibody, pot1.L antibody, Pot1a antibody, Pot1 antibody
    背景

    Background: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5\'-TTAGGG-3\' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5\'-TAGGGTTAG-3\' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3\'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.

    Aliases: DKFZP586D211 antibody, hPot 1 antibody, hPot1 antibody, POT 1 antibody, POT1 antibody, POT1 like telomere end-binding protein antibody, POT1 protection of telomeres 1 homolog antibody, POT1-like telomere end-binding protein antibody, POTE1_HUMAN antibody, Protection of telomeres 1 antibody, Protection of telomeres 1 homolog (S. pombe) antibody, Protection of telomeres protein 1 antibody

    UniProt
    Q9NUX5
    途径
    Cell Division Cycle, Telomere Maintenance
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