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POT1 抗体 (AA 250-432) (Biotin)

This anti-POT1 antibody is a 兔 多克隆 antibody detecting POT1 in ELISA. Suitable for 人.
产品编号 ABIN7164999
发货至: 中国

Quick Overview for POT1 抗体 (AA 250-432) (Biotin) (ABIN7164999)

抗原

See all POT1 抗体
POT1 (Protection of Telomeres 1 (POT1))

适用

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宿主

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克隆类型

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多克隆

标记

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This POT1 antibody is conjugated to Biotin

应用范围

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ELISA
  • 抗原表位

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    AA 250-432

    交叉反应

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human Protection of telomeres protein 1 protein (250-432AA)

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    POT1 (Protection of Telomeres 1 (POT1))

    别名

    POT1

    背景

    Background: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5\'-TTAGGG-3\' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5\'-TAGGGTTAG-3\' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3\'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.

    Aliases: DKFZP586D211 antibody, hPot 1 antibody, hPot1 antibody, POT 1 antibody, POT1 antibody, POT1 like telomere end-binding protein antibody, POT1 protection of telomeres 1 homolog antibody, POT1-like telomere end-binding protein antibody, POTE1_HUMAN antibody, Protection of telomeres 1 antibody, Protection of telomeres 1 homolog (S. pombe) antibody, Protection of telomeres protein 1 antibody

    UniProt

    Q9NUX5

    途径

    Cell Division Cycle, Telomere Maintenance
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