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PDCD6 抗体 (AA 1-191) (FITC)

PDCD6 适用: 人 宿主: 兔 Polyclonal FITC
产品编号 ABIN7164698
发货至: 中国
  • 抗原 See all PDCD6 抗体
    PDCD6 (Programmed Cell Death 6 (PDCD6))
    抗原表位
    • 15
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 1-191
    适用
    • 45
    • 12
    • 10
    宿主
    • 44
    • 2
    克隆类型
    • 44
    • 2
    多克隆
    标记
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This PDCD6 antibody is conjugated to FITC
    应用范围
    请咨询
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Programmed cell death protein 6 protein (1-191AA)
    亚型
    IgG
  • 限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    PDCD6 (Programmed Cell Death 6 (PDCD6))
    别名
    PDCD6 (PDCD6 产品)
    别名
    pdcd6 antibody, MGC52821 antibody, MGC132114 antibody, zgc:63952 antibody, PDCD6 antibody, ALG-2 antibody, PEF1B antibody, AV299538 antibody, Alg2 antibody, MA-3 antibody, PS2 antibody, alg-2 antibody, programmed cell death 6 L homeolog antibody, programmed cell death 6 antibody, pdcd6.L antibody, pdcd6 antibody, PDCD6 antibody, Pdcd6 antibody
    背景

    Background: Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca2+-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis, the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779).

    Aliases: AIP1 antibody, ALG 2 antibody, ALG-2-interacting protein 1 antibody, ALG2 antibody, ALIX antibody, Apoptosis linked gene 2 antibody, Apoptosis linked gene 2 protein antibody, Apoptosis-linked gene 2 protein antibody, FLJ42309 antibody, FLJ46208 antibody, Hp95 antibody, KIAA1375 antibody, MA 3 antibody, MA3 antibody, MGC111017 antibody, MGC119050 antibody, MGC9123 antibody, PDCD 6 antibody, Pdcd6 antibody, PDCD6_HUMAN antibody, PEF 1B antibody, PEF1B antibody, Probable calcium binding protein ALG 2 antibody, Probable calcium binding protein ALG2 antibody, Probable calcium-binding protein ALG-2 antibody, Programmed cell death 6 antibody, Programmed cell death 6-interacting protein antibody, Programmed cell death protein 6 antibody, PS 2 antibody, PS2 antibody

    UniProt
    O75340
    途径
    Positive Regulation of Endopeptidase Activity
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