PARG 抗体 (AA 1-348)
Quick Overview for PARG 抗体 (AA 1-348) (ABIN7163765)
抗原
See all PARG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-348
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Poly(ADP-ribose) glycohydrolase protein (1-348AA)
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亚型
- IgG
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anti-PARG (PARG) (AA 1-976) antibody
PARG 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-PARG (PARG) (AA 770-819) antibodyPARG 适用: 人, 豚鼠, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-PARG (PARG) (AA 777-976) antibodyPARG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-PARG (PARG) (AA 390-421), (C-Term) antibodyPARG 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14201-RB14549 unconjugated
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应用备注
- Recommended dilution: IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PARG
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别名
- PARG
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背景
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Background: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
Aliases: ADP riboseglycohydrolase antibody, Mitochondrial poly(ADP ribose) glycohydrolase antibody, Parg antibody, PARG_HUMAN antibody, PARG99 antibody, Poly antibody, poly (ADP ribose) glycohydrolase antibody, poly(ADP-ribose) glycohydrolase 60 kDa isoform antibody, Poly(ADP-ribose) glycohydrolase antibody
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UniProt
- Q86W56
抗原
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