SIRT7 抗体 (AA 242-379) (FITC)
Quick Overview for SIRT7 抗体 (AA 242-379) (FITC) (ABIN7160868)
抗原
See all SIRT7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 242-379
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human NAD-dependent protein deacetylase sirtuin-7 protein (242-379AA)
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亚型
- IgG
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anti-Sirtuin 7 (SIRT7) (AA 1-400) antibody
SIRT7 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 1-105) antibodySIRT7 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 1E2G10 unconjugated
anti-Sirtuin 7 (SIRT7) (AA 1-400) antibodySIRT7 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 201-400) antibodySIRT7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 1-105) antibodySIRT7 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1E2B2 unconjugated
anti-Sirtuin 7 (SIRT7) (AA 231-330) antibodySIRT7 适用: 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 242-379) antibodySIRT7 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 35-51), (AA 361-377) antibodySIRT7 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 8-350) antibodySIRT7 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 1-400) antibodySIRT7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SIRT7 (Sirtuin 7 (SIRT7))
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别名
- SIRT7
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背景
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Background: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at \'Lys-18\' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
Aliases: NAD dependent deacetylase sirtuin 7 antibody, NAD dependent protein deacetylase sirtuin 7 antibody, NAD-dependent protein deacetylase sirtuin-7 antibody, Regulatory protein SIR2 homolog 7 antibody, Silent mating type information regulation 2 homolog antibody, Silent mating type information regulation 2 S.cerevisiae homolog 7 antibody, SIR2 L7 antibody, SIR2 like protein 7 antibody, Sir2 related protein type 7 antibody, SIR2, S.CEREVISIAE, HOMOLOG-LIKE 7 antibody, SIR2-like protein 7 antibody, SIR2L 7 antibody, SIR2L7 antibody, SIR7_HUMAN antibody, SIRT 7 antibody, SIRT7 antibody, Sirtuin 7 antibody, Sirtuin type 7 antibody, Sirtuin7 antibody
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UniProt
- Q9NRC8
抗原
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