PLD6 抗体 (AA 1-252) (HRP)
Quick Overview for PLD6 抗体 (AA 1-252) (HRP) (ABIN7159840)
抗原
See all PLD6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-252
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Mitochondrial cardiolipin hydrolase protein (1-252AA)
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亚型
- IgG
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anti-Phospholipase D Family, Member 6 (PLD6) (AA 1-252) antibody
PLD6 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase D Family, Member 6 (PLD6) (AA 125-154) antibodyPLD6 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB28958 unconjugated
anti-Phospholipase D Family, Member 6 (PLD6) (AA 125-154) antibodyPLD6 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PLD6 (Phospholipase D Family, Member 6 (PLD6))
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别名
- PLD6
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背景
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Background: Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5\' phosphate and 3\' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579, PubMed:26711011).
Aliases: Choline phosphatase 6 antibody, Mitochondrial cardiolipin hydrolase antibody, Mitochondrial phospholipase antibody, MitoPLD antibody, Phosphatidylcholine hydrolyzing phospholipase D6 antibody, Phosphatidylcholine-hydrolyzing phospholipase D6 antibody, Phospholipase D family member 6 antibody, Phospholipase D6 antibody, PLD 6 antibody, pld6 antibody, PLD6_HUMAN antibody, Protein zucchini homolog antibody, ZUC antibody, Zucchini, Drosophila, homolog of antibody
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UniProt
- Q8N2A8
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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