MFGE8 抗体
Quick Overview for MFGE8 抗体 (ABIN7159679)
抗原
See all MFGE8 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人
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纯化方法
- Protein G purified
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免疫原
- Recombinant Human MFGE8 protein
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亚型
- IgG2b
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anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) (AA 1-200) antibody
MFGE8 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) antibodyMFGE8 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal MFG-06 unconjugated
anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) (AA 159-417) antibodyMFGE8 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) (AA 73-421) antibodyMFGE8 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) antibodyMFGE8 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) antibodyMFGE8 适用: 人 IHC, FACS, IF, StM 宿主: 小鼠 Monoclonal EDM45 unconjugated
anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) antibodyMFGE8 适用: 人, 犬 WB, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal MFG-06 unconjugated
anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) antibodyMFGE8 适用: 人 WB, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal SPM291 unconjugated
anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) (AA 25-334) antibodyMFGE8 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) (AA 1-387) antibodyMFGE8 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution:IHC:1:50-1:500,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))
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别名
- MFGE8
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背景
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Background: Human MFGE8(milk fat globule-EGF factor 8,also lactadherin, breast epithelial antigen BA46, and medin) is a 46 kDa, secreted, monomeric glycoprotein that is associated with the human milk fat globule (HMFG) membrane.It is expressed by mammary epithelial cell surfaces, artery media, and in several carcinomas .Human MGFE8 is synthesized as a 387 amino acid (aa) precursor that contains a 23 aa signal sequence and a 364 aa mature region. The mature molecule contains four Nlinked glycosylation sites, an aminoterminal EGF like domain, plus C1 and C2 Iglike domains which are related to discoidin I and homologous to those of human coagulation factors V and VIII . Within the EGF like domain is an ArgGlyAsp(RGD) sequence, which is strategically placed in a hairpin loop between two antiparallel beta strands. In this way, the EGFlike domain serves as a scaffold for the RGD sequence, which is proposed to promote cell adhesion by binding cellsurface integrin receptors, such as ??v??3. Human MFGE8 shares 59 % , 58 %, 56 %, and 52 % aa sequence identity with porcine, bovine, rat, and mouse MFGE8,respectively. Functionally, MFGE8 in milk is reported to block rotavirus infection . MFGE8 expression by macrophages promotes the phagocytosis of apoptotic thymocytes by forming a bridge between phosphatidylserine on apoptotic cells, and ??v??3 integrin on phagocytes . The MFGE8 expression by macrophages controls the accumulation of apoptotic membrane fragments in atherosclerotic plaques and substantially limits lesion development .
Aliases: Lactadherin,Breast epithelial antigen,BA46 ,HMFG,MFGM Milk fat globule-EGF factor 8
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UniProt
- Q08431
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途径
- SARS-CoV-2 Protein Interactome
抗原
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