MAGEA2 抗体 (AA 1-104)
Quick Overview for MAGEA2 抗体 (AA 1-104) (ABIN7159256)
抗原
See all MAGEA2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-104
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Melanoma-associated antigen 2 protein (1-104AA)
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亚型
- IgG
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anti-Melanoma Antigen Family A, 2 (MAGEA2) (AA 1-314) antibody
MAGEA2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H4 unconjugated
anti-Melanoma Antigen Family A, 2 (MAGEA2) (AA 1-314) antibodyMAGEA2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1B1 unconjugated
anti-Melanoma Antigen Family A, 2 (MAGEA2) (AA 23-72) antibodyMAGEA2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Melanoma Antigen Family A, 2 (MAGEA2) (AA 81-108), (N-Term) antibodyMAGEA2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB2194 unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- MAGEA2 (Melanoma Antigen Family A, 2 (MAGEA2))
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别名
- MAGEA2
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背景
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Background: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.
Aliases: MAGEA2 antibody, MAGE2 antibody, MAGEA2A, antibody, MAGEA2B antibody, MAGE2 antibody, MAGEA2 antibody, Melanoma-associated antigen 2 antibody, Cancer/testis antigen 1.2 antibody, CT1.2 antibody, MAGE-2 antigen antibody
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UniProt
- P43356
抗原
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