LAPTM4B 抗体 (AA 174-226)
Quick Overview for LAPTM4B 抗体 (AA 174-226) (ABIN7158792)
抗原
See all LAPTM4B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 174-226
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Lysosomal-associated transmembrane protein 4B protein (174-226AA)
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亚型
- IgG
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anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 195-209) antibody
LAPTM4B 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal RB42294 unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (Internal Region) antibodyLAPTM4B 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (Middle Region) antibodyLAPTM4B 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 兔, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 216-265) antibodyLAPTM4B 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 218-317) antibodyLAPTM4B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))
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别名
- LAPTM4B
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背景
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Background: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).
Aliases: LAPTM4B antibody, PSEC0001 antibody, Lysosomal-associated transmembrane protein 4B antibody, Lysosome-associated transmembrane protein 4-beta antibody
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UniProt
- Q86VI4
抗原
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