KLHL2 抗体 (AA 1-200)
Quick Overview for KLHL2 抗体 (AA 1-200) (ABIN7157277)
抗原
See all KLHL2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-200
-
交叉反应
- 人
-
纯化方法
- >95%, Protein G purified
-
免疫原
- Recombinant Human Kelch-like protein 20 protein (1-200AA)
-
亚型
- IgG
-
-
anti-Kelch-Like 2, Mayven (KLHL2) (AA 1-100), (AA 494-593) antibody
KLHL2 适用: 人, 犬, 猴 WB, IF, FACS 宿主: 小鼠 Monoclonal 1G7 unconjugated
anti-Kelch-Like 2, Mayven (KLHL2) (AA 1-155) antibodyKLHL2 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 2, Mayven (KLHL2) (AA 1-100), (AA 494-593) antibodyKLHL2 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 3H9 unconjugated
anti-Kelch-Like 2, Mayven (KLHL2) (AA 1-100), (AA 494-593) antibodyKLHL2 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 8B8 unconjugated
anti-Kelch-Like 2, Mayven (KLHL2) (AA 1-66) antibodyKLHL2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G3 unconjugated
anti-Kelch-Like 2, Mayven (KLHL2) (AA 1-593) antibodyKLHL2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Kelch-Like 2, Mayven (KLHL2) (AA 179-228) antibodyKLHL2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 猴, 兔, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 2, Mayven (KLHL2) (Middle Region) antibodyKLHL2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- KLHL2 (Kelch-Like 2, Mayven (KLHL2))
-
别名
- KLHL2
-
背景
-
Background: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates \\\'Lys-33\\\'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating \\\'Lys-33\\\'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).
Aliases: Kelch like ECT2 interacting protein antibody, Kelch like protein 20 antibody, Kelch like protein X antibody, Kelch motif containing protein antibody, Kelch-like ECT2-interacting protein antibody, Kelch-like protein 20 antibody, Kelch-like protein X antibody, KHLHX antibody, KLEIP antibody, KLH20_HUMAN antibody, KLHL20 antibody, KLHLX antibody, RP3-383J4.3 antibody
-
UniProt
- Q9Y2M5
抗原
-
