IL12B 抗体 (AA 23-328)
Quick Overview for IL12B 抗体 (AA 23-328) (ABIN7156785)
抗原
See all IL12B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 23-328
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交叉反应
- 人, 小鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Interleukin-12 subunit beta protein (23-328AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- IL12B (Interleukin 12 beta (IL12B))
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别名
- IL12B
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背景
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Background: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Ref.12Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Aliases: CLMF antibody, CLMF p40 antibody, CLMF2 antibody, Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody, IL 12B antibody, IL-12 subunit p40 antibody, IL-12B antibody, IL12 p40 antibody, IL12B antibody, IL12B_HUMAN antibody, IMD28 antibody, IMD29 antibody, Interleukin 12 beta chain antibody, Interleukin 12 p40 antibody, Interleukin-12 subunit beta antibody, NK cell stimulatory factor chain 2 antibody, NKSF antibody, NKSF2 antibody
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UniProt
- P29460
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途径
- JAK/STAT Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
抗原
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