KPNA5 抗体 (AA 1-240)
Quick Overview for KPNA5 抗体 (AA 1-240) (ABIN7156130)
抗原
See all KPNA5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-240
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交叉反应
- 人, 小鼠
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Importin subunit alpha-6 protein (1-240AA)
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亚型
- IgG
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anti-Karyopherin alpha 5 (Importin alpha 6) (KPNA5) (AA 1-539) antibody
KPNA5 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 1D2 unconjugated
anti-Karyopherin alpha 5 (Importin alpha 6) (KPNA5) (AA 1-539) antibodyKPNA5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 5 (Importin alpha 6) (KPNA5) (N-Term) antibodyKPNA5 适用: 人, 小鼠 WB, ELISA, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 5 (Importin alpha 6) (KPNA5) (AA 434-483) antibodyKPNA5 适用: 人, Cow, 犬, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 5 (Importin alpha 6) (KPNA5) (N-Term) antibodyKPNA5 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))
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别名
- KPNA5
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背景
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Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Aliases: IMA5_HUMAN antibody, Importin alpha 6 antibody, Importin subunit alpha 6 antibody, Importin subunit alpha-6 antibody, IPOA 6 antibody, IPOA6 antibody, Karyopherin alpha 5 antibody, Karyopherin alpha 5 importin alpha 6 antibody, Karyopherin subunit alpha 5 antibody, Karyopherin subunit alpha-5 antibody, KPNA 5 antibody, KPNA5 antibody, SRP 6 antibody, SRP6 antibody
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UniProt
- O15131
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途径
- Protein targeting to Nucleus
抗原
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