Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) 抗体 (Biotin)
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Quick Overview for Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) 抗体 (Biotin) (ABIN7156074)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-112
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原理
- vpx Antibody, Biotin conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-112AA)
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亚型
- IgG
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anti-Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) antibody
HIV Vpx 适用: Human Immunodeficiency Virus (HIV) ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Human Immunodeficiency Virus Vpx (HIV Vpx)
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别名
- HIV vpx
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物质类
- Viral Protein
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背景
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Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).
Aliases: vpxProtein Vpx antibody, Viral protein X antibody, X ORF protein antibody
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UniProt
- P06939
抗原
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