ALOXE3 抗体 (AA 1-280)
Quick Overview for ALOXE3 抗体 (AA 1-280) (ABIN7155980)
抗原
See all ALOXE3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-280
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Hydroperoxide isomerase ALOXE3 protein (1-280AA)
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亚型
- IgG
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anti-Arachidonate Lipoxygenase 3 (ALOXE3) (AA 1-280) antibody
ALOXE3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate Lipoxygenase 3 (ALOXE3) antibodyALOXE3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate Lipoxygenase 3 (ALOXE3) (AA 223-252) antibodyALOXE3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB17172 unconjugated
anti-Arachidonate Lipoxygenase 3 (ALOXE3) (AA 1-711) antibodyALOXE3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate Lipoxygenase 3 (ALOXE3) (AA 1-711) antibodyALOXE3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))
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别名
- ALOXE3
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背景
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Background: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.
Aliases: ALOXE3 antibody, Arachidonate lipoxygenase 3 antibody, e LOX 3 antibody, E LOX antibody, e-LOX-3 antibody, eLOX3 antibody, Epidermal lipoxygenase antibody, Epidermis-type lipoxygenase 3 antibody, Lipoxygenase 3 antibody, LOXE3_HUMAN antibody
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UniProt
- Q9BYJ1
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途径
- Cell-Cell Junction Organization
抗原
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