HRG 抗体 (AA 412-511) (HRP)
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北京 101111
Quick Overview for HRG 抗体 (AA 412-511) (HRP) (ABIN7155261)
抗原
See all HRG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 412-511
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原理
- HRG Antibody, HRP conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human Histidine-rich glycoprotein protein (412-511AA)
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亚型
- IgG
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anti-Histidine-Rich Glycoprotein (HRG) (AA 19-525) antibody
HRG 适用: 大鼠 WB, IHC 宿主: 小鼠 Monoclonal C3 unconjugated
anti-Histidine-Rich Glycoprotein (HRG) (AA 18-254) antibodyHRG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histidine-Rich Glycoprotein (HRG) (AA 106-302) antibodyHRG 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histidine-Rich Glycoprotein (HRG) (AA 93-328) antibodyHRG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histidine-Rich Glycoprotein (HRG) (AA 18-254) antibodyHRG 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D2 unconjugated
anti-Histidine-Rich Glycoprotein (HRG) (AA 412-511) antibodyHRG 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Histidine-Rich Glycoprotein (HRG) antibodyHRG 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Histidine-Rich Glycoprotein (HRG) (AA 1-525) antibodyHRG 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Histidine-Rich Glycoprotein (HRG) (AA 1-525) antibodyHRG 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Histidine-Rich Glycoprotein (HRG) (AA 19-200) antibodyHRG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- HRG (Histidine-Rich Glycoprotein (HRG))
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别名
- HRG
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背景
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Background: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway, inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis.
Aliases: HRG antibody, Histidine-rich glycoprotein antibody, Histidine-proline-rich glycoprotein antibody, HPRG antibody
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UniProt
- P04196
抗原
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