HPSE 抗体 (AA 263-523)
Quick Overview for HPSE 抗体 (AA 263-523) (ABIN7155022)
抗原
See all HPSE 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 263-523
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Heparanase protein (263-523AA)
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亚型
- IgG
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anti-Heparanase (HPSE) (AA 34-115) antibody
HPSE 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 353-464) antibodyHPSE 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 40-188) antibodyHPSE 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 280-412) antibodyHPSE 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 400-543) antibodyHPSE 适用: 人 WB, ICC, IF 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Heparanase (HPSE) (AA 68-117) antibodyHPSE 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) antibodyHPSE 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 36-275) antibodyHPSE 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 72-170) antibodyHPSE 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D7 unconjugated
anti-Heparanase (HPSE) (AA 54-278) antibodyHPSE 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- HPSE (Heparanase (HPSE))
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别名
- HPSE
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背景
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Background: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
Aliases: Endo glucoronidase antibody, Endo-glucoronidase antibody, HEP antibody, Heparanase 50 kDa subunit antibody, Heparanase antibody, Heparanase-1 antibody, Heparanase1 antibody, Hpa 1 antibody, HPA antibody, Hpa1 antibody, HPR 1 antibody, HPR1 antibody, HPSE 1 antibody, HPSE antibody, HPSE_HUMAN antibody, HPSE1 antibody, HSE 1 antibody, HSE1 antibody
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UniProt
- Q9Y251
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途径
- Glycosaminoglycan Metabolic Process
抗原
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