HSPA1L 抗体 (AA 420-641) (Biotin)
Quick Overview for HSPA1L 抗体 (AA 420-641) (Biotin) (ABIN7154848)
抗原
See all HSPA1L 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 420-641
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Heat shock 70 kDa protein 1-like protein (420-641AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- HSPA1L (Heat Shock 70kDa Protein 1-Like (HSPA1L))
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别名
- HSPA1L
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背景
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Background: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).
Aliases: Heat shock 70 kDa protein 1 Hom antibody, Heat shock 70 kDa protein 1 like antibody, Heat shock 70 kDa protein 1-Hom antibody, Heat shock 70 kDa protein 1-like antibody, Heat shock 70 kDa protein 1L antibody, Heat shock 70kD protein like 1 antibody, HS71L_HUMAN antibody, HSP70 1L antibody, HSP70 HOM antibody, HSP70-Hom antibody, HSPA1L antibody, hum70t antibody, Spermatid specific heat shock protein 70 antibody
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UniProt
- P34931
抗原
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