GPR161 抗体 (AA 1-28) (FITC)
Quick Overview for GPR161 抗体 (AA 1-28) (FITC) (ABIN7153329)
抗原
See all GPR161 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-28
-
交叉反应
- 人
-
纯化方法
- >95%, Protein G purified
-
免疫原
- Recombinant Human G-protein coupled receptor 161 protein (1-28AA)
-
亚型
- IgG
-
-
-
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- GPR161 (G Protein-Coupled Receptor 161 (GPR161))
-
别名
- GPR161
-
背景
-
Background: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
Aliases: GPR161 antibody, G-protein coupled receptor 161 antibody, G-protein coupled receptor RE2 antibody
-
UniProt
- Q8N6U8
-
途径
- cAMP Metabolic Process
抗原
-