GRK5 抗体 (AA 406-590) (Biotin)
Quick Overview for GRK5 抗体 (AA 406-590) (Biotin) (ABIN7153298)
抗原
See all GRK5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 406-590
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human G protein-coupled receptor kinase 5 protein (406-590AA)
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亚型
- IgG
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anti-G Protein-Coupled Receptor Kinase 5 (GRK5) (AA 371-590) antibody
GRK5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 5 (GRK5) antibodyGRK5 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 5 (GRK5) (AA 559-590), (C-Term) antibodyGRK5 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB0903 unconjugated
anti-G Protein-Coupled Receptor Kinase 5 (GRK5) (AA 406-590) antibodyGRK5 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 5 (GRK5) (Internal Region) antibodyGRK5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 5 (GRK5) (AA 393-429), (C-Term) antibodyGRK5 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 5 (GRK5) (N-Term) antibodyGRK5 适用: 人, Cow, 犬 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 5 (GRK5) (Internal Region) antibodyGRK5 适用: 人, 小鼠, 大鼠, Cow, 马, 小鸡, 猴, Pig, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 5 (GRK5) (Internal Region) antibodyGRK5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor Kinase 5 (GRK5) (AA 290-339) antibodyGRK5 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 斑马鱼, 小鸡, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- GRK5 (G Protein-Coupled Receptor Kinase 5 (GRK5))
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别名
- GRK5
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背景
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Background: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).
Aliases: FLJ39780 antibody, FP2025 antibody, G protein coupled receptor kinase 5 antibody, G protein coupled receptor kinase GRK5 antibody, G protein-coupled receptor kinase 5 antibody, G protein-coupled receptor kinase GRK5 antibody, GPRK5 antibody, GRK-pan antibody, GRK5 antibody, GRK5_HUMAN antibody, Pan-GRK antibody
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UniProt
- P34947
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途径
- Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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