FBXL2 抗体 (AA 1-423) (HRP)
Quick Overview for FBXL2 抗体 (AA 1-423) (HRP) (ABIN7152475)
抗原
See all FBXL2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-423
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA)
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亚型
- IgG
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anti-F-Box and Leucine-Rich Repeat Protein 2 (FBXL2) (N-Term) antibody
Verified FBXL2 适用: 人 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-F-Box and Leucine-Rich Repeat Protein 2 (FBXL2) (N-Term) antibodyFBXL2 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-F-Box and Leucine-Rich Repeat Protein 2 (FBXL2) (AA 366-395), (C-Term) antibodyFBXL2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB30004 unconjugated
anti-F-Box and Leucine-Rich Repeat Protein 2 (FBXL2) (AA 1-137) antibodyFBXL2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-F-Box and Leucine-Rich Repeat Protein 2 (FBXL2) (AA 1-423) antibodyFBXL2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-F-Box and Leucine-Rich Repeat Protein 2 (FBXL2) (AA 71-120) antibodyFBXL2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠, 兔, 斑马鱼, Bat, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-F-Box and Leucine-Rich Repeat Protein 2 (FBXL2) (AA 120-240) antibodyFBXL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-F-Box and Leucine-Rich Repeat Protein 2 (FBXL2) (N-Term) antibodyFBXL2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-F-Box and Leucine-Rich Repeat Protein 2 (FBXL2) antibodyFBXL2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- FBXL2 (F-Box and Leucine-Rich Repeat Protein 2 (FBXL2))
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别名
- FBXL2
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背景
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Background: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).
Aliases: DKFZP564P0622 antibody, F box and leucine rich repeat protein 2 antibody, F box protein containing leucine rich repeats antibody, F box protein FBL2/FBL3 antibody, F box/LRR repeat protein 2 antibody, F-box and leucine-rich repeat protein 2 antibody, F-box protein FBL2/FBL3 antibody, F-box/LRR-repeat protein 2 antibody, FBL 2 antibody, FBL 3 antibody, FBL2 antibody, FBL3 antibody, FBXL 2 antibody, FBXL2 antibody, FBXL2_HUMAN antibody
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UniProt
- Q9UKC9
抗原
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