FBXO6 抗体 (AA 104-293)
Quick Overview for FBXO6 抗体 (AA 104-293) (ABIN7152447)
抗原
See all FBXO6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 104-293
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human F-box only protein 6 protein (104-293AA)
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亚型
- IgG
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anti-F-Box Protein 6 (FBXO6) (AA 1-293) antibody
FBXO6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 6 (FBXO6) (AA 1-293) antibodyFBXO6 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3F10 unconjugated
anti-F-Box Protein 6 (FBXO6) (AA 1-293) antibodyFBXO6 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 7D1 unconjugated
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应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- FBXO6 (F-Box Protein 6 (FBXO6))
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别名
- FBXO6
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背景
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Background: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on \\\'Ser-345\\\'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
Aliases: F box protein that recognizes sugar chains 2 antibody, F box G domain protein 2 antibody, F box only protein 6 antibody, F box protein 6 antibody, F box protein FBG2 antibody, F box protein Fbx6 antibody, F box/G domain protein 2 antibody, F-box only protein 6 antibody, F-box protein that recognizes sugar chains 2 antibody, F-box/G-domain protein 2 antibody, FBG 2 antibody, FBG2 antibody, FBS 2 antibody, FBS2 antibody, FBX 6 antibody, FBX6 antibody, FBX6_HUMAN antibody, FBXO 6 antibody, FBXO6 antibody, OTTHUMP00000002267 antibody
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UniProt
- Q9NRD1
抗原
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